All 243 Guns and How to Get Them in Enter the Gungeon

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Showing 58 of 243 items.

Quality

C

68 items

Anvillain

Fires piercing anvils with high knockback and a chance to stun.

Quality: C
Firing Type: Charged
Damage: 35
DPS: 47.7
Magazine: 3
Ammo: 60
Reload Time: 0.5
Unlockable: No
Unlock Requirement: -
Synergies: Hammer and Anvil — If the player has Cobalt Hammer, firing the Cobalt Hammer 's charge attack also sends out anvils in all directions.
Heavy Metal — If the player also has Heavy Bullets or Heavy Boots, damage is increased by 20% and shot speed is decreased by 25%.

Bait Launcher

Fires a steak that causes a tiger to appear and maul the target.

Quality: C
Firing Type: Charged
Damage: 10 / 50
DPS: 40.0
Magazine: 1
Ammo: 60
Reload Time: 1.0
Unlockable: Yes
Unlock Requirement: Kill the High Dragun with Beast Mode on.
Synergies: Cat Friend — If the player has Cat Claw, Bait Launcher's tigers attach several Cat Claw needles onto enemies when they maul them.

Balloon Gun

Fires small homing tornadoes.

Quality: C
Firing Type: Automatic
Damage: 12
DPS: 44.1
Magazine: 10
Ammo: 250
Reload Time: 1.6
Unlockable: No
Unlock Requirement: -
Synergies: Get Equipped With -A- — If the player has Megahand, enables Air Shooter mode on Megahand, which fires Balloon Gun tornadoes while uncharged. Modes can be switched by reloading the Megahand with a full magazine.
Paper Lanterns — If the player also has Origuni, while holding either gun in a room with enemies, paper lanterns periodically spawn, which drift towards enemies and deal damage.
Three Sheets — If the player also has Corsair, movement speed is increased, the damage of both guns is doubled, and their bullets travel 20% faster.

Banana

Fires an explosive banana that sends out three more bouncing explosive bananas.

Quality: C
Firing Type: Charged
Damage: 10 / 30
DPS: 15.0
Magazine: 7
Ammo: 50
Reload Time: 0.01
Unlockable: No
Synergies: Hornucopia — If the player has Charm Horn, the explosive banana will send out five bouncing explosive bananas instead of three, one of which explodes into 4 additional exploding bananas. Additionally, using Charm Horn fires a banana at each enemy it charms. Banana must be equipped to get this effect.

Barrel

Fires a fish that has a chance to stun and leaves a pool of water on impact.

Quality: C
Firing Type: Semiautomatic
Damage: 8
DPS: 30.3
Magazine: 9
Ammo: 300
Reload Time: 0.78
Unlockable: No
Synergies: Like Shooting Fish — If the player has Backup Gun, a fish pops out of the barrel and fires bullets. The last shot of each magazine fires a fish that flops around on the ground and fires at enemies.
One Fish Two Fish — If the player has Helix Bullets, with each shot, Barrel fires one normal blue fish and one red fish that sets enemies on fire.
Siren Sidearm — If the player has Siren, the first shot of every Siren magazine fires two fish, and every Barrel shot fires a Siren water bubble.

Bow

Fully charged shots pierce.

Quality: C
Firing Type: Charged
Damage: 7.5 / 30
DPS: 26.8
Magazine: 1
Ammo: 100
Reload Time: 0.12
Unlockable: No
Synergies: Cerebral Bros — If the player also has Bullet Bore, Bullet Bore turns red and fires two drills at a time.
Diazepam — Muscle Relaxant increases this gun's damage by 50%.
Fairy Bow — If the player also has Bomb, charge time is halved and the Bow has a chance to fire an extra arrow, similar to the Shadow Bullets effect. It also gives Cat Bullet King Throne the same effect when the bow is held even though it's not part of the synergy.
Slings and Arrows — If the player has Sling, the Bow can be charged longer to fire a special arrow that deals 50 damage.
Sniper Woof — If the player has Wolf, Bow's reload time is decreased by 30%. Standing still for long enough causes the player to glow yellow, making the Bows shots deal 50% more damage. Sniper Shells and Professionals that spawn while Bow is held become permanently charmed.

Boxing Glove

Shoots a boxing glove with a chance to stun.

Quality: C
Firing Type: Charged
Damage: 12 / 200
DPS: 30.0
Magazine: 350
Ammo: 350
Reload Time: 1.5
Unlockable: Yes
Unlock Requirement: Defeat the first two phases of the Resourceful Rat.
Synergies: -

Brick Breaker

Fires piercing turtle shells that bounce off of walls.

Quality: C
Firing Type: Semiautomatic
Damage: 10
DPS: 15.6
Magazine: 5
Ammo: 200
Reload Time: 1.2
Unlockable: Yes
Unlock Requirement: Complete the Keep of the Lead Lord 50 times.
Synergies: Block Party — If the player also has Mustache, the size of the Brick Breaker's shells is increased by 50%, and their damage is increased by 25%.
Softshell — If the player also has Stuffed Star, while Stuffed Star is active, Brick Breaker shells are continually fired in random directions.
Circle of Bricks — If the player also has the Tetrominator, both guns are dual-wielded.

Bubble Blaster

Fires bubbles which move slowly towards enemies.

Quality: C
Firing Type: Automatic
Damage: 12
DPS: 105.3
Magazine: 100
Ammo: 500
Reload Time: 1.4
Unlockable: No
Unlock Requirement: -
Synergies: Bubble Trouble — If the player has Siren, Siren will fire a single large shot that deals 18 damage, and Bubble Blaster's shots home in on enemies.
Get Equipped With -B- — If the player has Megahand, enables Bubble Lead mode on Megahand, which fires Bubble Blaster shots while uncharged. Modes can be switched by reloading the Megahand with a full magazine.

Bullet

Fires rotating guns which fire bullets as they travel.

Quality: C
Firing Type: Semiautomatic
Damage: 7 / 4
DPS: 21.0
Magazine: 6
Ammo: 250
Reload Time: 1.0
Unlockable: No
Unlock Requirement: -
Synergies: Blammo! — If the player also has Shell, the guns are dual-wielded.

Bundle of Wands

Has a chance to transmogrify.

Quality: C
Firing Type: Semiautomatic
Damage: 7 x 3 (21 total)
DPS: 42.0
Magazine: 6
Ammo: 150
Reload Time: 1.5
Unlockable: Yes
Unlock Requirement: Reward from hunting quests.
Synergies: Cast Iron — If the player has Big Iron, each of Big Iron 's bullets are replaced with one from Bundle of Wands, Witch Pistol, and Hexagun.
Chicken Arise — If the player has Magic Bullets, the chance for Bundle of Wands to transmogrify is increased.
Special Delivery — If the player has Owl, Bundle of Wands's and Owl 's shots bounce. The Owl turns skeletal and fires letters.

Buzzkill

Fires piercing, bouncing sawblades.

Quality: C
Firing Type: Semiautomatic
Damage: 7
DPS: 24.7
Magazine: 12
Ammo: 350
Reload Time: 1.2
Unlockable: No
Unlock Requirement: -
Synergies: Get Equipped With -M- — If the player has Megahand, enables Metal Blade mode on Megahand, which fires Buzzkill shots while uncharged. Modes can be switched by reloading the Megahand with a full magazine.
I Studied The Blade — If the player has Super Meat Gun, the two guns are dual wielded.
Not So Sawed-Off — If the player has Rattler, Regular Shotgun, or Winchester, Buzzkill's saw blades move slower and are linked with lightning.

Cactus

Fires needles.

Quality: C
Firing Type: Automatic
Damage: 2.5
DPS: 25.0
Magazine: 1,000
Ammo: 1,000
Reload Time: 0.0
Unlockable: No
Unlock Requirement: -
Synergies: Cactus Flower — If the player has Broccoli or Orange, Cactus has a chance to fire a prickly pear that bounces off walls and fires needles in all directions. The chance to fire a prickly pear also applies to guns Duct Tape to Cactus with the synergy.
Vegetables — If the player also has Broccoli, Cactus's damage is tripled, needle size is doubled, and needles pierce enemies and bounce off obstacles.
Pea Cannon — If the player has Pea Shooter, its shots become larger, deal more damage, and explode.
Succulent DOOM — If the player has Starpew, every Cactus shot fires a spread of 5 needles.
Thorn Bath, ooh! — If the player has Armor of Thorns, Cactus's damage is increased by 30%. While holding Cactus, nails are periodically fired in all directions.

Camera

Damages all enemies in the room, with a chance to stun.

Quality: C
Firing Type: Charged
Damage: 10
DPS: 15.4
Magazine: 4
Ammo: 60
Reload Time: 2.0
Unlockable: No
Unlock Requirement: -
Synergies: Camera Shy — If the player has Chaff Grenade, the Camera has a chance to stun enemies.
Get Equipped with -F- — If the player has Megahand, enables Time Stopper on Megahand, which briefly stops time on a charged shot for 1.5 seconds.
Just Shoot Me — If the player has Magazine Rack, it shoots at nearby enemies while active.
Ice Cap — If the player also has Freeze Ray, the Ray freezes enemies much quicker.
Savior of the Universe — If the player has Flash Ray, it gains unlimited piercing, a thicker beam, one bounce, increased fire rate, and causes a Camera flash when reloading an empty magazine. Camera also fires two laser beams whenever fired at full charge.

Chamber Gun

Transforms based on the current chamber.

Quality: C
Firing Type: Semiautomatic
Damage: Varies
DPS: Varies
Magazine: Varies
Ammo: Varies
Reload Time: Varies
Unlockable: Yes
Unlock Requirement: Visit all Chambers at least once.
Synergies: Master's Chambers — Each Master Round the player carries permanently unlocks the mode of its respective floor. Reloading the Chamber Gun with a full magazine cycles through the unlocked modes. This synergy does not work with Lich's Eye Bullets.

Colt 1851

Fires a burst of two bullets.

Quality: C
Firing Type: Burst
Damage: 6
DPS: 28.2
Magazine: 12
Ammo: 350
Reload Time: 1.5
Unlockable: No
Synergies: All Out Of Law — If the player has Table Tech Sight, Escape Rope, Hip Holster, or Heart Holster, Colt 1851 fires three tight spreads of three bullets upon reloading. These projectiles do not use ammo, and they can reveal secret rooms without angering the shopkeeper Bello.
Cold 1896 — If the player has Cold 45, both guns' magazine sizes are doubled, and the guns are dual-wielded. If the player also has (All Out Of Law) and the Cold 45 is the primary weapon, reloading will fire from the Cold instead.
Reload Roll — If the player also has Easy Reload Bullets, dodge rolling reloads six bullets. This synergy does not function if obtained through the Lich's Eye Bullets.
Two Kinds of People — If the player has Knight's Gun, it will always dig up something when reloading with an empty clip (instead of digging and finding nothing).

Corsair

Fires slow, bouncing bullets that accelerate and curve towards enemies before exploding.

Quality: C
Firing Type: Charged
Damage: 10 / 40
DPS: 12.5
Magazine: 1
Ammo: 200
Reload Time: 0.5
Unlockable: No
Synergies: Black Flag — If the player also has Grappling Hook or Serious Cannon, each Corsair shot will periodically fire two bouncing cannonballs perpendicular to itself as it travels. The stats of the cannonballs are closer to those fired by Dueling Pistol rather than Serious Cannon.
Swift Sloop — If the player also has Sense of Direction, increases Corsair's shot speed by 50%, decreases its charge time by 33%, and decreases its reload time by 20%.
Three Sheets — If the player also has Balloon Gun, movement speed is increased, the damage of both guns is doubled, and their bullets travel 20% faster.
Unsinkable — If the player has Glacier, Corsair fires exploding Titanic ships.

Crestfaller

Inflicts Freeze.

Quality: C
Firing Type: Semiautomatic
Damage: 10
DPS: 18.4
Magazine: 8
Ammo: 250
Reload Time: 1.2
Unlockable: No
Synergies: Crestfallen Soul — If the player also has Gun Soul, dodge roll speed is increased by 20% and Crestfaller deals 50% more damage if the player dies and has not yet retrieved their soul.
Five O'Clock Somewhere — If the player also has Shotga Cola, Shotgun Coffee, Double Vision, Potion of Gun Friendship, Potion of Lead Skin, or Old Knight's Flask, reloading will fire a glass bottle that has a chance to stun enemies hit. Reloading while standing on a liquid replenishes the ammo missing in the current magazine, similar to Gungine. As with Gungine, pressing the reload button while the clip is full will still clear liquids.

Crown of Guns

Sits atop the player's head and fires bullets in all directions.

Quality: C
Firing Type: Automatic
Damage: 5.5
DPS: 220.0
Magazine: 3,000
Ammo: 3,000
Reload Time: 2.0
Unlockable: No
Unlock Requirement: -
Synergies: Alas, Sniperion — If the player also has Crescent Crossbow, Crown of Guns becomes Sailor Moon's tiara and shoots crescent shaped bullets that do more damage.
Blast Crown — If the player has Blast Helmet, Crown of Guns gains a chance to fire explosives.
Great Queen Ant — If the player has Gungeon Ant, it turns into an ant queen that fires rocket ants.
King Bomber — If the player has Lil' Bomber, its bombs spawn every time they hit an enemy.
Poseigun — If the player has Trident, Crown of Guns randomly fires Trident beams, while Trident fires a spread of three beams per shot, no longer benefits from rolling, has its magazine size decreased to 8, and has its fire rate reduced greatly.
Two Heavy — If the player also has Coin Crown, the chance for Coin Crown to spawn money upon clearing a room is doubled.
Usurper — If the player has Cat Bullet King Throne, the Crown fires more rapidly and also automatically charms Bullet Kin and Veteran Bullet Kin when held. This charm effect seems to persist on the Bullet Kins after it activates, even if you switch your gun afterwards.

Devolver

Has a chance to devolve enemies into simpler enemies.

Quality: C
Firing Type: Semiautomatic
Damage: 6
DPS: 24.1
Magazine: 6
Ammo: 100
Reload Time: 0.78
Unlockable: Yes
Unlock Requirement: Purchase from Alien merchant – Doug for 10 Hegemony Credit.
Synergies: Contractual Obligation — If the player has Gungine, a pool of oil spawns underneath enemies killed using it.
Cool Kids Club — If the player has Strafe Gun, continuously moving with the Strafe Gun held gives the player a yellow glow, increasing movement speed. The glow disappears if the player stops moving.
Serious Sam Publishing Contract — If the player has Serious Cannon, alongside the cannonball, Serious Cannon fires a screaming Beheaded Kamikaze who chases enemies and explodes on contact.

Dungeon Eagle

Can be charged to fire more powerful shots.

Quality: C
Firing Type: Charged
Damage: 10 / 20
DPS: 32.1
Magazine: 9
Ammo: 200
Reload Time: 1.2
Unlockable: No
Unlock Requirement: -
Synergies: Don't Hoot the Messenger — If the player also has Owl, halves time required to fire a charged shot.
Reload Roll — If the player also has Easy Reload Bullets, dodge rolling reloads six bullets and dodge rolling range is slightly increased while holding the weapon. Dodge roll distance is increased if the player has Lich's Eye Bullets but does not reload the gun.

Elephant Gun

Fires a cone spread of bullets with high knockback.

Quality: C
Firing Type: Semiautomatic
Damage: 5.5 x 6 (33 total)
DPS: 31.4
Magazine: 2
Ammo: 120
Reload Time: 1.5
Unlockable: Yes
Unlock Requirement: Reward from hunting quests.
Synergies: Iron Stance — If the player also has Heavy Boots, the gun's damage and knockback are increased by 20%, its shot speed is increased by 50%, and its reload time is decreased by 20%.
The Elephant In The Room — If the player also has Pig, Turkey, Owl, Chicken Flute, Super Space Turtle, Bait Launcher, or Compressed Air Tank the Elephant Gun becomes an elephant head and shoots a pink elephant instead of bullets. The elephant deals 30 damage and has strong knockback, but decreased fire rate. If the player has The Elephant In The Room and Bumbullets, an apparent bug causes bees to be fired at the original fire rate of the non-synergised Elephant Gun, while only firing the Elephant-shaped bullets at the expected fire rate of the upgraded version. This results in the player being able to fire three shots per reload by rapidly pulling or holding down the trigger, with the second shot being just a single bee, and the third shot not being followed by a bee at all. If the player waits between the first and second shot, until the 2nd Elephant In The Room shot is ready to fire, then the second shot will behave as expected, firing both an elephant and a bee.

Evolver

Killing enemies evolves the gun through 6 forms.

Quality: C
Firing Type: Semiautomatic
Damage: 6 to 37.5
DPS: 13.5 to 93.8
Magazine: 8 to 300
Ammo: 300 / 150
Reload Time: 1.5
Unlockable: Yes
Unlock Requirement: Purchase from Goop merchant – Professor Goopton for 35 Hegemony Credit.
Synergies: Natural Selection — If the player also has Irradiated Lead, Monster Blood or Big Boy, the gun evolves after every 3 unique enemy types.

Gamma Ray

Fires a green laser that slightly curves towards enemies and can poison.

Quality: C
Firing Type: Beam
Damage: 16/s
DPS: 16.0
Magazine: 800
Ammo: 800
Reload Time: -
Unlockable: Yes
Unlock Requirement: Purchase from Breach shopkeeper – Ox for 2 Hegemony Credit.
Synergies: Beta Ray — If the player also has Irradiated Lead, Gamma Ray's beam grows larger and deals more damage, but no longer travels instantaneously.
Gungeonite — If the player also has Clear Guon Stone, Gamma Ray will leave a trail of poison.
Meltdown — If the player also has Big Boy, Gamma Ray branches twice to form a spread of 5 beams and using Big Boy refills 100 ammo on the Gamma Ray. Ammo restoration only works if Gamma Ray is held when activating Big Boy. Additionally this synergy also affects Orbital Bullets, creating several large rings that pull enemies toward the ring.

Glass Cannon

Fires a powerful beam.

Quality: C
Firing Type: Charged
Damage: 140
DPS: 50.0
Magazine: 1
Ammo: 25
Reload Time: 2.0
Unlockable: No
Unlock Requirement: -
Synergies: Max Pane — If the player has Glass Guon Stone, Glass Cannon will change appearance and will not break if the player takes damage. Instead, the Guon Stones will be destroyed, losing the synergy but granting one extra hit before it breaks.

Gungeon Ant

In oil mode, creates oil puddles on impact.

Quality: C
Firing Type: Semiautomatic
Damage: 2 x 3 (6 total) / 1.5 x 3 (4.5 total)
DPS: 30.0
Magazine: 6
Ammo: 100
Reload Time: 1.2
Unlockable: No
Unlock Requirement: -
Synergies: Buggin' Out — If the player has Bug Boots, while Gungeon Ant is held, Bug Boots spread oil instead of poison, and the player is immune to fire.
Great Queen Ant — If the player also has Crown of Guns, Heck Blaster, Gilded Bullets, Coin Crown, or Ring of Fire Resistance, Gungeon Ant loses the alternating attack and instead fires explosive ants that destroy enemy bullets when exploding and deals ≥ 30 damage each.
Inconsistent Scale — If the player also has Bee Hive, while Gungeon Ant is held, a beehive orbits the player that send bees out towards enemies.

Gunslinger's Ashes

Fires slow homing ghosts that shoot and deal contact damage.

Quality: C
Firing Type: Semiautomatic
Damage: 12 / 5
DPS: 21.4
Magazine: 6
Ammo: 80
Reload Time: 1.2
Unlockable: Yes
Unlock Requirement: Feed 10 guns to Evil Munchers. This can be done over the course of multiple runs.
Synergies: Dawn of the Gundead — If the player has Zombie Bullets, the chance for Gunslinger's Ashes ammo to be refunded upon missing is doubled.
Ghost With The Most — If the player has Ghost Bullets or Ring of Ethereal Form, the ghosts become larger and can freeze enemies. Reload time is decreased by 20%.

Hegemony Carbine

Shoots rapid fire white bolts of energy.

Quality: C
Firing Type: Automatic
Damage: 3.5
DPS: 23.0
Magazine: 25
Ammo: 600
Reload Time: 1.4
Unlockable: Yes
Unlock Requirement: Purchase from Breach shopkeeper – Ox for 3 Hegemony Credit.
Synergies: Decorated — If the player has Galactic Medal of Valor, the Hegemony Carbine's shots are tripled.
Ruby Carbine — If the player also has Ruby Bracelet, Cog Of Battle, or Mimic Tooth Necklace, the Hegemony Carbine will turn red and its shots will bounce off of walls once and burn enemies.

Helix

Fires two bullets in a helix pattern.

Quality: C
Firing Type: Semiautomatic
Damage: 7.5 x 2 (15 total)
DPS: 34.0
Magazine: 12
Ammo: 250
Reload Time: 2.0
Unlockable: No
Unlock Requirement: -
Synergies: Double Double Helix — If the player also has Helix Bullets, instead of the Helix Bullets effect being applied to each bullet, Helix's projectiles will be doubled (2 bullets will fire on each side while following the original pattern), damage is increased by 25%, and shot speed is increased by 50%.

Huntsman

Reloading destroys nearby bullets and knocks back enemies.

Quality: C
Firing Type: Semiautomatic
Damage: 3.5 x 6 (21 total)
DPS: 28.3
Magazine: 6
Ammo: 150
Reload Time: 1.2
Unlockable: No
Unlock Requirement: -
Synergies: -

JK-47

Reloading inflicts fear on nearby enemies.

Quality: C
Firing Type: Automatic
Damage: 5.5
DPS: 18.9
Magazine: 30
Ammo: 500
Reload Time: 1.5
Unlockable: No
Synergies: The Killing Joke — If the player also has AK-47, the two guns are dual-wielded.
Soft Air — If the player also has Sponge, when holding the JK-47, the player regains ammo when walking over liquids, and increases fear range while reloading. If the player has both synergies at once, AK-47 will also regain ammo when walking over liquids if it is the selected gun of the dual-wield.

Laser Rifle

Fires a burst of three lasers.

Quality: C
Firing Type: Burst
Damage: 5
DPS: 25.5
Magazine: 24
Ammo: 500
Reload Time: 1.2
Unlockable: No
Synergies: Diazepam — If the player also has Muscle Relaxant, the gun's damage is increased by 50%.
Laser Light Show — If the player also has Scattershot, Laser Rifle becomes blue and gold, and fires 3 sets of 3 shots in a spread per trigger pull. Each shot bounces once.
Starburst Fire — If the player also has The Emperor, firing either The Emperor or Laser Rifle once will cause it to rapidly fire its entire magazine. Increases damage by 20% and doubles fire rate. You can cancel the effect by reloading or dodge-rolling while firing.

Luxin Cannon

Fires laser shots at enemies.

Quality: C
Firing Type: Automatic
Damage: 4.5 / 24 / 5
DPS: 43.8
Magazine: 30
Ammo: 600
Reload Time: 1.5
Unlockable: No
Synergies: Bullet Kiln — If the player has Elder Blank, using it while Luxin Cannon is held gives one Glass Guon Stone, up to a maximum of four. Uses of Elder Blank triggered by Full Metal Jacket do not grant a Glass Guon Stone.
Crystal Horn — If the player has Unicorn Horn, the Luxin Cannon gets three crystal shots at the end of every magazine, and the crystal bursts into many more crystals. Additionally, when an enemy is killed with the Unicorn Horn, they explode into Luxin Cannon projectiles.
Noxin Cannon — If the player has Shadow Bullets, or Cursed Bullets, Luxin Cannon and its shots turn gray, and the lasers deal 25% more damage.
The Return — If the player has Pig, it turns green and shoots fire bats.

M1

Fires high-speed piercing bullets.

Quality: C
Firing Type: Semiautomatic
Damage: 20
DPS: 22.6
Magazine: 6
Ammo: 100
Reload Time: 1.3
Unlockable: No
Synergies: Diazepam — Muscle Relaxant increases this gun's damage by 50%.
M1 Multi-Tool — If the player also has Scope, Drum Clip, Ammo Belt, Backpack, or Utility Belt, M1's reload time is decreased by 20%, its magazine size is increased by 50%, and its maximum ammo is increased by 80%. Movement speed is also increased while M1 is held.
Mmmmmmmmm MMMMmm! — If the player also has M16 and M1911, the damage, maximum ammo, and rate of fire of all three guns is increased by 25%.
Smile, you son of a... — If the player has Compressed Air Tank, its sharks will explode upon biting an enemy. These shark explosions can damage the player.
Sniper Woof — If the player has Wolf, M1's reload time is decreased by 30%. Standing still for long enough causes the player to glow yellow, making M1 shots deal 50% more damage. Sniper Shells and Professionals become permanently charmed.

M1911

Fires standard semiautomatic pistol rounds.

Quality: C
Firing Type: Semiautomatic
Damage: 8
DPS: 26.0
Magazine: 7
Ammo: 200
Reload Time: 1.2
Unlockable: No
Synergies: Behold! — If the player also has Com4nd0, Eye of the Beholster, Void Marshal, Machine Pistol, and Trank Gun (the weapons the Beholster uses in game), when the Eye of the Beholster is held, the other five guns rotate around the player and shoot at nearby enemies, still using up ammo from each gun. Obtainable through the Beholster shrine, although it can be activated without.
Mmmmmmmmm MMMMmm! — If the player also has M1 and M16, increases the damage, maximum ammo, and fire rate of all three guns by 25%.
Pulp Gungeon — If the player also has Orange, a copy of the M1911 orbits the player and fires whenever the player fires. The synergy will be lost once the Orange is used.
Reload Roll — If the player also has Easy Reload Bullets, dodge rolling reloads six bullets. This synergy does not function if obtained through the Lich's Eye Bullets.

MAC10

Fires a burst of four bullets.

Quality: C
Firing Type: Burst
Damage: 3.5
DPS: 34.7
Magazine: 30
Ammo: 600
Reload Time: 1.0
Unlockable: No
Synergies: Iroquois — If the player also has Eyepatch, Rolling Eye, or Cigarettes, the MAC10's reload time is decreased by 33%, magazine size is increased by 50%, and knockback is increased by 50%.
The Submachinist — If the player also has Machine Pistol, both weapons are dual wielded and are fired simultaneously.

Mahoguny

Fires bouncing explosive seed cones and several leaves.

Quality: C
Firing Type: Semiautomatic
Damage: 5 / 10 / 4
DPS: 56.3
Magazine: 10
Ammo: 350
Reload Time: 1.2
Unlockable: No
Synergies: Get Equipped With -W- — If the player also has Megahand, enables Leaf Shield mode on Megahand, which fires leaves when uncharged and regular Megahand shots when fully charged. Killing enemies causes leaves to orbit the player, blocking enemy shots. Modes can be switched by reloading the Megahand with a full magazine.
Hardwood — If the player also has Decoy, Explosive Decoy, Heavy Boots, or Broccoli, Mahoguny fires four explosive pinecones at a time, and no longer fires leaves.
Lumberjacked — If the player also has Huntsman, the guns' damage are increased by 25%.
Pea Cannon — If the player also has Pea Shooter, Pea Shooter shots become larger, deal more damage, and explode.

Molotov Launcher

Fires molotovs that create fire puddles on impact.

Quality: C
Firing Type: Semiautomatic
Damage: 6
DPS: 2.4
Magazine: 1
Ammo: 80
Reload Time: 2.5
Unlockable: No
Synergies: Special Reserve — If the player has Hot Lead, Napalm Strike, or Double Vision, Molotovs create green fire pools. Green fire does not damage the player, and enemies that touch green fire are permanently set aflame. The green flame from the synergy Special Reserve will not activate Sprun, even if being lit on fire is the activation trigger.

Moonscraper

Fires a beam that reflects off of solid objects once.

Quality: C
Firing Type: Beam
Damage: 26/s
DPS: 26.0
Magazine: 700
Ammo: 700
Reload Time: -
Unlockable: No
Synergies: Jumping... Is Useless — If the player also has Quad Laser, four Moonscraper laser beams shoot from each side of Quad Laser 's bullets. Doubles Quad Laser 's shot speed and triples its reload time.
Klobbering Time — If the player also has Klobbe, its shots are doubled.
Land Among The Stars — If the player also has Crescent Crossbow, killing enemies with Moonscraper has a chance to send out three planet Earths, which damage enemies and start orbiting the player if they fail to hit an enemy.
Moonplanet — If the player also has Mr. Accretion Jr., a little planet orbits the player that blocks enemy shots on contact.

Origuni

Fires paper planes that follow the player's crosshair.

Quality: C
Firing Type: Semiautomatic
Damage: 7.5
DPS: 22.5
Magazine: 8
Ammo: 300
Reload Time: 1.2
Unlockable: Yes
Unlock Requirement: Purchase from Breach shopkeeper – Ox for 6 Hegemony Credit.
Synergies: Blade Runner — If the player also has Deck4rd, magazine size of both guns is increased by 50%.
Paperwork — If the player also has the Ballot or any Table Tech item except for Table Tech Heat or Table Tech Shotgun ( Table Tech Blanks, Table Tech Money, Table Tech Rage, Table Tech Rocket, Table Tech Sight, or Table Tech Stun ), the first shot after reloading will fire three planes.
Paper Lanterns — If the player has Balloon Gun, while holding either gun in a room with enemies, paper lanterns periodically spawn, which drift towards enemies and deal damage.
Parchmental — If the player has picked up a Map at any point during the run, the gun changes appearance and two planes are fired per shot. This lasts for the rest of the run even though the Map only lasts for one floor. Saving and quitting will remove this synergy unless another Map is picked up.

Pitchfork

Fires piercing fireballs that burn.

Quality: C
Firing Type: Semiautomatic
Damage: 4
DPS: 26.7
Magazine: 100
Ammo: 200
Reload Time: 0.0
Unlockable: No
Unlock Requirement: -
Synergies: Hail, Satan! — If the player has Demon Head, Demon Head gains piercing.
Hotter Than Heck — If the player has Flame Hand, the shot size and damage of the guns are increased by 25%, and grants fire immunity while either gun is held.
Pitch Perfect — If the player has Sixth Chamber, Yellow Chamber, or Holey Grail, Pitchfork fires green fireballs that set enemies, but not bosses, permanently aflame.

Plunger

Fires a stream of poison.

Quality: C
Firing Type: Beam
Damage: 5/s
DPS: 5.0
Magazine: 500
Ammo: 500
Reload Time: -
Unlockable: Yes
Unlock Requirement: Purchase from Goop merchant – Professor Goopton for 7 Hegemony Credit.
Synergies: Super Serum — If the player also has Hazmat Suit or the Gas Mask, the Plunger's ammo capacity is increased by 50%, its projectiles can bounce, and the size of the projectiles increases.

Poxcannon

Shoots poisonous t-shirts with high knockback.

Quality: C
Firing Type: Semiautomatic
Damage: 15
DPS: 26.1
Magazine: 6
Ammo: 250
Reload Time: 1.7
Unlockable: No
Synergies: -

Pulse Cannon

Fires a shotgun blast spread of 6 bullets.

Quality: C
Firing Type: Semiautomatic
Damage: 4 x 6 (24 total)
DPS: 41.7
Magazine: 8
Ammo: 120
Reload Time: 1.8
Unlockable: No
Synergies: Finger on the Pulse — If the player has Heart Bottle, Heart Holster, Heart Purse, Heart Locket, or Heart Lunchbox and takes damage while holding Pulse Cannon, three temporary Pulse Cannons spawn around the player and fire at enemies, before disappearing. This effect stacks with itself, each hit adding 3 more pulse cannons. The functional maximum is 6 though, due to invincibility frames limiting how much damage can be taken within the lifespan of one set of cannons.
Iron Stance — If the player also has Heavy Boots, projectile speed and knockback are increased.
The Return — If the player has Pig, it turns green and shoots fire bats.

Quad Laser

Fires a large, square, extremely slow bullet.

Quality: C
Firing Type: Semiautomatic
Damage: 80
DPS: 53.3
Magazine: 1
Ammo: 50
Reload Time: 1.5
Unlockable: No
Synergies: Jumping... is useless — If the player also has Moonscraper, four laser beams shoot from each side of Quad Laser's bullets. If the player drops either Quad Laser or Moonscraper, or switches to another weapon after firing, the four lasers will stay in place and stop following the Quad Laser bullet. Doubles Quad Laser's shot speed and triples its reload time.
Primitive Shapes — If the player has Tangler, Quad Laser's shots become rectangular and travel faster. Tangler 's shots become much larger and deal 50% more damage, but travel very slowly.
some even larger number — If the player has Triple Gun, killing an enemy will cause it to shoot out a Quad Laser shot aimed towards the nearest enemy.

Really Special Lute

Fires in a very wide spread.

Quality: C
Firing Type: Automatic
Damage: 6 x 7 (42 total)
DPS: 82.5
Magazine: 75
Ammo: 300
Reload Time: 1.2
Unlockable: Yes
Unlock Requirement: Purchase from Alien merchant – Doug for 28 Hegemony Credit.
Synergies: Three Part Harmony — If the player also has Metronome, the gun's spread is drastically decreased.

Screecher

Rapidly fires piercing sound waves that have a small chance to stun.

Quality: C
Firing Type: Automatic
Damage: 1.5
DPS: 30.0
Magazine: 1,000
Ammo: 1,000
Reload Time: 0.6
Unlockable: No
Unlock Requirement: -
Synergies: Banshee Cry — If the player has Dueling Laser, the Screecher fires a cone of three waves per shot.

Shades's Revolver

Increases coolness by 3.

Quality: C
Firing Type: Semiautomatic
Damage: 15
DPS: 30.0
Magazine: 6
Ammo: 150
Reload Time: 1.5
Unlockable: No
Unlock Requirement: -
Synergies: Trigger Twins — If the player also has Smiley's Revolver, ammo capacity is doubled and magazine size is increased by 50% for all guns, and the two guns will be dual wielded. While Lich's Eye Bullets doesn't give the dual wielding portion of the synergy, it will give the 2x ammo capacity and 50% magazine size increase.

Shotgrub

Shots leave small pools of poison goop.

Quality: C
Firing Type: Semiautomatic
Damage: 5 x 5 (25 total)
DPS: 46.5
Magazine: 8
Ammo: 250
Reload Time: 1.5
Unlockable: No
Synergies: Contrail — If the player has Alien Engine, its flame turns green, igniting enemies with green fire. Alien Engine also grants flight while held.
Just Like The Real Thing — If the player has Sixth Chamber, Yellow Chamber, Holey Grail, or Bullet Idol, Shotgrub's bullets will act like those of the Shotgrub enemy, no longer causing poison, firing in a static spread, but gaining penetration and splitting into wavy bullets upon hitting a wall or enemy.
Monster Grub — If the player also has Monster Blood, Shotgrub's bullets will home in on enemies.

Silencer

Fires zippers.

Quality: C
Firing Type: Semiautomatic
Damage: 13
DPS: 14.0
Magazine: 8
Ammo: 200
Reload Time: 1.5
Unlockable: No
Synergies: -

Siren

Fires a shotgun blast of bullets that leave pools of water.

Quality: C
Firing Type: Semiautomatic
Damage: 6 x 3 (18 total)
DPS: 32.0
Magazine: 6
Ammo: 200
Reload Time: 1.5
Unlockable: No
Synergies: Brave New World — If the player also has Trident or Bionic Leg, while Siren is held, a fish companion follows the player that can block bullets and shows contents of chests without opening them.
Bubble Trouble — If the player has Bubble Blaster, Siren will fire a single large shot that deals 18 damage, and Bubble Blaster 's shots home in on enemies.
Iron Stance — If the player has Heavy Boots, increases Siren's damage and knockback by 20%, increases shot speed by 50%, and decreases reload time by 20%.
Siren Sidearm — If the player also has Barrel, the first shot of every Siren magazine fires two fish, and every Barrel shot fires a Siren water bullet.

Skull Spitter

Fires homing skulls.

Quality: C
Firing Type: Semiautomatic
Damage: 10
DPS: 27.0
Magazine: 10
Ammo: 150
Reload Time: 1.0
Unlockable: No
Synergies: Dawn of the Gundead — If the player also has Zombie Bullets, the chance for Skull Spitter ammo to be refunded upon missing is doubled.
Jolly Roger — If the player has the VertebraeK-47, it gets the ability to freeze enemies, while Skull Spitter fires 3 skulls that are linked together.

Sniper Rifle

Fires long-range rounds that pierce through one enemy.

Quality: C
Firing Type: Semiautomatic
Damage: 26
DPS: 24.8
Magazine: 10
Ammo: 80
Reload Time: 1.5
Unlockable: No
Synergies: 360 Yes Scope — If the player also has Scope, spinning 360 degrees before firing grants a 3-second buff that makes the next shot deal 50% more damage. This can be activated multiple times, providing a stacking 1.5x damage multiplier for each spin. It caps at 6 rotations.
Diazepam — Muscle Relaxant increases this gun's damage by 50%.
Sniper Woof — If the player also has Wolf, Sniper Rifle's reload time is decreased by 30%. Standing still for long enough causes the player to glow yellow, making Sniper Rifle shots deal 50% more damage. Sniper Shells and Professionals become permanently charmed.

Sticky Crossbow

Fires bolts that stick to enemies and explode upon reloading.

Quality: C
Firing Type: Semiautomatic
Damage: 5 / 15
DPS: 30.0
Magazine: 6
Ammo: 100
Reload Time: 1.5
Unlockable: No
Synergies: Triple Sticky — If the player also has Triple Crossbow, Sticky Crossbow will fire three bolts per shot. Triple Crossbow 's triple shot will explode upon hitting an enemy.

Tangler

Fires a spread of bouncing bullets.

Quality: C
Firing Type: Semiautomatic
Damage: 6 x 6 (36 total)
DPS: 43.6
Magazine: 4
Ammo: 150
Reload Time: 1.5
Unlockable: Yes
Unlock Requirement: Purchase from Breach shopkeeper – Ox for 10 Hegemony Credit.
Synergies: Iron Stance — If the player also has Heavy Boots, the gun's damage and knockback are increased by 20%, its shot speed is increased by 50%, and its reload time is decreased by 20%.
Primitive Shapes — If the player also has Quad Laser, Tangler's shots become much larger and deal 50% more damage, but travel very slowly. Quad Laser 's shots become rectangles and travel faster.
Spengbab — If the player also has Sponge, knockback and range are increased by 50%.
Full Circle — If the player also has Rolling Eye, Tangler appears round instead of rectangular. Deals increased damage and turns enemies round instead of rectangular, but reloads slower (2.0 seconds).

Teapot

While reloading, ignites nearby enemies.

Quality: C
Firing Type: Semiautomatic
Damage: 8.5 / 15
DPS: 14.7
Magazine: 12
Ammo: 250
Reload Time: 3.0
Unlockable: No
Unlock Requirement: -
Synergies: Monsters and Monocles — If the player also has Mustache, the AoE effect range of Teapot is increased.
Tea for Two — If the player has almost any familiar (including Ser Junkan, Wolf, Turkey, Clown Mask, Chicken Flute, Baby Good Mimic, Baby Good Shelleton, Pig, R2G2, Super Space Turtle, Blank Companion's Ring, or Badge ), the familiar will have the AoE effect while reloading. While Dog and Turtle Problem will not activate this synergy, they will gain the AoE effect if another familiar activates it.

Tear Jerker

Fires tears that leave behind puddles of water.

Quality: C
Firing Type: Semiautomatic
Damage: 7
DPS: 26.0
Magazine: 20
Ammo: 350
Reload Time: 1.2
Unlockable: No
Unlock Requirement: -
Synergies: Tears of Blood — If the player has Bloody Eye, Tear Jerker's shots turn red and inflict slow.
Wrath Of The Blam — If the player has Directional Pad, Tear Jerker is replaced with a crying bullet head that can only fire in cardinal directions but deals double damage. The shots fired by this head will still have the properties of the original Tear Jerker bullets, so they will move as the player moves.

The Kiln

Fires pots that break into 3 bouncing crystals upon hitting something.

Quality: C
Firing Type: Semiautomatic
Damage: 8 / 4 x 3 (12 total)
DPS: 16.0
Magazine: 8
Ammo: 200
Reload Time: 1.2
Unlockable: No
Synergies: Bullet Kiln — If the player has Elder Blank, using it while The Kiln is held gives one Glass Guon Stone, up to a maximum of four. The limit can be worked around by dropping excess glass guon stones on the floor before using the Elder Blank, and then collecting them again.
Hot Head — If the player has Stone Dome, Stone Dome shots burn enemies.

C