Slay the Spire 2 is a card game where you build a deck and fight your way up through a different path each run. Potions are the bottles you carry alongside your cards. Drink one during a fight and you get an instant boost, like heavy damage, a shield called Block, or healing. Knowing what each one does can make the difference in a tough battle.
Rarity
Common
Attack Potion
Offers three random Attacks and adds your choice to your hand for free this turn.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Choose 1 of 3 random Attack cards to add into your Hand. It's free to play this turn.
Block Potion
Adds 12 Block.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Gain 12 Block.
Blood Potion
Restores one fifth of your maximum HP.
- Rarity
- Common
- Character Pool
- Ironclad
- Effect
- Heal for 20% of your Max HP.
Colorless Potion
Offers three random Colorless cards and adds your choice for free this turn.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Choose 1 of 3 random Colorless cards to add into your Hand. It's free to play this turn.
Dexterity Potion
Adds two Dexterity.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Gain 2 Dexterity.
Energy Potion
Gives two Energy.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Gain 2 Energy.
Explosive Ampoule
Deals 10 damage to every enemy.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Deal 10 damage to ALL enemies.
Fire Potion
Deals 20 damage to one target.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Deal 20 damage.
Flex Potion
Adds Strength this turn, then removes the same amount at turn end.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Gain 5 Strength. At the end of your turn, lose 5 Strength.
Focus Potion
Adds two Focus.
- Rarity
- Common
- Character Pool
- Defect
- Effect
- Gain 2 Focus.
Poison Potion
Applies six Poison.
- Rarity
- Common
- Character Pool
- Silent
- Effect
- Apply 6 Poison.
Potion of Doom
Applies 33 Doom.
- Rarity
- Common
- Character Pool
- Necrobinder
- Effect
- Apply 33 Doom.
Power Potion
Offers three random Powers and adds your choice to your hand for free this turn.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Choose 1 of 3 random Power cards to add into your Hand. It's free to play this turn.
Skill Potion
Offers three random Skills and adds your choice to your hand for free this turn.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Choose 1 of 3 random Skill cards to add into your Hand. It's free to play this turn.
Speed Potion
Adds Dexterity this turn, then removes the same amount at turn end.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Gain 5 Dexterity. At the end of your turn, lose 5 Dexterity.
Star Potion
Gives three Stars.
- Rarity
- Common
- Character Pool
- Regent
- Effect
- Gain 3 Stars.
Strength Potion
Adds two Strength.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Gain 2 Strength.
Swift Potion
Draws three cards.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Draw 3 cards.
Vulnerable Potion
Applies three Vulnerable.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Apply 3 Vulnerable.
Weak Potion
Applies three Weak.
- Rarity
- Common
- Character Pool
- All characters
- Effect
- Apply 3 Weak.
Rarity
Uncommon
Ashwater
Lets you clear unwanted cards from your hand.
- Rarity
- Uncommon
- Character Pool
- Ironclad
- Effect
- Exhaust any number of cards in your Hand.
Blessing of the Forge
Upgrades every card in your hand for the rest of combat.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Upgrade all cards in your Hand for the rest of combat.
Bone Brew
Adds 15 Summon.
- Rarity
- Uncommon
- Character Pool
- Necrobinder
- Effect
- Summon 15.
Clarity Extract
Draws a card now and one extra card at the start of your next three turns.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Draw 1 card. At the start of your next 3 turns, draw 1 additional card.
Cunning Potion
Adds three upgraded Shivs to your hand.
- Rarity
- Uncommon
- Character Pool
- Silent
- Effect
- Add 3 Upgraded Shivs into your Hand.
Cure All
Gives one Energy and draws two cards.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Gain 1 Energy. Draw 2 cards.
Duplicator
Makes your next card play an extra time this turn.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- This turn, your next card is played an extra time.
Fortifier
Triples your Block.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Triple your Block.
Fysh Oil
Adds one Strength and one Dexterity.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Gain 1 Strength and 1 Dexterity.
Gambler's Brew
Lets you discard any number of cards, then draw the same number.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Discard any number of cards, then draw that many.
Heart of Iron
Adds seven Plating.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Gain 7 Plating.
King's Courage
Adds 15 Forge.
- Rarity
- Uncommon
- Character Pool
- Regent
- Effect
- Forge 15.
Liquid Bronze
Adds three Thorns.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Gain 3 Thorns.
Potion of Binding
Applies Weak and Vulnerable to every enemy.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Apply 1 Weak and 1 Vulnerable to ALL enemies.
Potion of Capacity
Adds two Orb Slots.
- Rarity
- Uncommon
- Character Pool
- Defect
- Effect
- Gain 2 Orb Slots.
Powdered Demise
Makes an enemy lose nine HP at the end of each of its turns.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Enemy loses 9 HP at the end of each of its turns.
Radiant Tincture
Gives one Energy now and one more at the start of each of your next three turns.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Gain 1 Energy. Gain an additional 1 Energy at the start of your next 3 turns.
Regen Potion
Gives five Regen.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Gain 5 Regen.
Stable Serum
Retains your hand for two turns.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Retain your Hand for 2 turns.
Touch of Insanity
Makes one chosen card free to play for the rest of combat.
- Rarity
- Uncommon
- Character Pool
- All characters
- Effect
- Choose a card in your Hand. It is free to play this combat.
Rarity
Rare
Beetle Juice
Reduces enemy attack damage for four turns.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Enemy's attacks deal 30% less damage for the next 4 turns.
Bottled Potential
Reshuffles your cards, then draws five.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Shuffle ALL your cards into your Draw Pile. Draw 5 cards.
Cosmic Concoction
Adds three upgraded Colorless cards to your hand.
- Rarity
- Rare
- Character Pool
- Regent
- Effect
- Add 3 Upgraded Colorless cards into your Hand.
Distilled Chaos
Plays the top three cards of your draw pile.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Play the top 3 cards of your Draw Pile.
Droplet of Precognition
Moves one chosen draw-pile card into your hand.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Choose a card in your Draw Pile and add it into your Hand.
Entropic Brew
Fills every empty potion slot with a random potion.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Fill all your empty potion slots with random potions.
Essence of Darkness
Channels a Dark for each of your Orb Slots.
- Rarity
- Rare
- Character Pool
- Defect
- Effect
- Channel a Dark for each of your Orb Slots.
Fairy in a Bottle
Prevents a fatal hit and restores 30% of your maximum HP.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- When your HP would be reduced to 0, instead this potion is discarded and you heal to 30% of your Max HP.
Fruit Juice
Raises your maximum HP by five.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Gain 5 Max HP.
Ghost in a Jar
Gives one Intangible.
- Rarity
- Rare
- Character Pool
- Silent
- Effect
- Gain 1 Intangible.
Gigantification Potion
Triples the damage of your next Attack.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- The next Attack you play deals triple damage.
Liquid Memories
Returns one card from your discard pile and makes it free this turn.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Put a card from your Discard Pile into your Hand. It's free to play this turn.
Lucky Tonic
Adds one Buffer.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Gain 1 Buffer.
Mazaleth's Gift
Adds one Ritual.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Gain 1 Ritual.
Orobic Acid
Adds a random Attack, Skill, and Power to your hand for free this turn.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Add a random Attack, Skill, and Power into your Hand. They're free to play this turn.
Pot of Ghouls
Adds two Souls to your hand.
- Rarity
- Rare
- Character Pool
- Necrobinder
- Effect
- Add 2 Souls into your Hand.
Shackling Potion
Removes seven Strength from every enemy this turn.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- ALL enemies lose 7 Strength this turn.
Ship in a Bottle
Adds ten Block now and another ten next turn.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Gain 10 Block. Next turn, gain 10 Block.
Snecko Oil
Draws seven cards and randomizes the costs of cards in your hand this turn.
- Rarity
- Rare
- Character Pool
- All characters
- Effect
- Draw 7 cards. Randomize the cost of cards in your Hand this turn.
Soldier's Stew
Gives every card containing Strike one extra Replay this combat.
- Rarity
- Rare
- Character Pool
- Ironclad
- Effect
- All cards containing Strike gain 1 Replay this combat.
Rarity
Event
Foul Potion
Damages all players and enemies, or can be thrown at the Merchant for Gold.
- Rarity
- Event
- Character Pool
- All characters
- Effect
- Deal 12 damage to ALL players and enemies. Can be thrown at the Merchant for 100 Gold instead.
Glowwater Potion
Exhausts your hand, then draws ten cards.
- Rarity
- Event
- Character Pool
- All characters
- Effect
- Exhaust your Hand. Draw 10 cards.
Rarity
Special
Potion-Shaped Rock
Deals 15 damage.
- Rarity
- Special
- Character Pool
- All characters
- Effect
- Deal 15 damage.
How Potions Work in Slay the Spire 2
A potion is a single-use item. You drink it, it takes effect right away, and it's gone. Drinking one costs no Energy, the resource you spend to play cards each turn, and it doesn't count as playing a card. That means a potion adds power on top of the cards you already have.
Most potions are meant for battles, so you'll usually drink them mid-fight when a boost matters most.
Potion Rarities: Common, Uncommon and Rare
Potions are sorted into groups by how often you find them. Common potions show up most often, and they're mostly simple ones like Block, Fire and Strength. Uncommon potions sit in the middle, and Rare potions are the hardest to find in a normal run.
Event and special potions form a small separate group. You get them from specific places rather than regular drops.
Character Potions and the Shared Pool
Potions come in two kinds. Most are shared, so any character can find them. Each of the five characters, Ironclad, Silent, Defect, Necrobinder and Regent, also has three potions of their own, one for each of the Common, Uncommon and Rare groups. A Silent run can find Poison Potion, Cunning Potion and Ghost in a Jar, and other characters can't.
Because the shared pool is much larger, most of the potions you find will come from it.
Where to Find Potions in Slay the Spire 2
Winning fights is one of the main ways to get potions. Elite enemies, the tougher fights, add extra chances, so they're worth paying attention to. Events, the Merchant and some card effects can also hand you potions.
Opening choices at the start of a run and some relics add potions too. The Phial Holster option, for example, gives you two random potions and an extra slot to hold them. You can only carry a few at a time, so it's worth deciding which ones to keep.
Event and Special Potions
Foul Potion is one of the more useful picks in this group. It deals 12 damage to everyone in the fight, including you, but you can also throw one at the Merchant for 100 Gold instead. Glowwater Potion works differently: it exhausts your hand, which takes those cards out of play for the rest of the fight, and then draws ten new cards. Potion-Shaped Rock is simpler and deals 15 damage.
Which Potions Matter Most
Some potions change how an entire fight goes, and those are the ones players tend to hold onto. Fairy in a Bottle is a safety net that can save you from a fatal blow. Gigantification Potion makes your next attack deal triple damage, which can take down a tough elite in one swing. Fortifier triples the Block you already have, so it shines when your deck is built around a shield.
Duplicator plays your next card twice, and Liquid Memories brings a card back from your discard pile into your hand for free. Entropic Brew fills your empty slots with random potions, which is handy when you have room to spare.
The basic stat potions, like Strength, Dexterity, Flex and Speed, give smaller boosts and tend to help less in big fights. They still have a place when your deck is built around them, but stronger picks are usually the better choice.
When to Drink Your Potions
Most players save their best potions for elite fights and bosses, where a shorter battle means less damage taken. Using one on an ordinary enemy early in a run often wastes it. Early on you can be a bit more relaxed, since you'll have more chances to find potions.
Matching the potion to the fight matters too. Poison Potion is strong against enemies with lots of health but adds little in a quick fight. Block is best used on the turn you need it, since it wears off before your next turn.
Try not to walk into the final boss with empty slots. Holding a couple of potions for that fight is usually a good move.
FAQ
Do potions stay with you between floors?
Yes. A potion you pick up stays in your slots until you use it, so you can save one for a boss several floors later.
What happens if you die holding a Fairy in a Bottle?
Instead of dropping to zero, you're healed to 30% of your max HP, and the fight keeps going. The potion is discarded when it triggers, so it only saves you once.